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KMID : 0370019900040000022
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Chung-Ang Journal of Pharmacal Sciences
1990 Volume.4 No. 0 p.22 ~ p.31
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The Effects of Rehmanniae Radices Extracts on Streptozotocin-Induced Hyperglycemia in Rats
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Abstract
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The studies were attempted to compare the antidiabetic activities of Relumanniae Radices on the hyperglycemia induced by streptozotocin in rats.
The water fractions and methanol fractions of roots of Rehmanniae Radices were administered before and after injection of streptozotocin(45mg / kg, i.p.), and blood glucose, serum cholesterol and serum triglyceride levels were determined at 96 hours after streptozotocin injection.
The results were following ;
1. The blood glucose levels of streptozotocin-induced hyperglycemic rats were dose-dependently decreased by the administrations of various fractions of the Relunanniae Radices. Partivularly, the administrations of the water fractions(200mg / kg, p.o.) of Rehmanniae radix siccata and Rehmanniae radix preparata were significantly shown to diminish when comparing with streptozotocin control group.
2. The serum total cholesterol levels of streptozotocin-induced hyperglycemic rats were significantly decreased by the administrations of the water fractions(100mg / kg, 200mg / kg, p.o.) of Rehmanniae Radices. But, the nethanol fractions(100mg / kg, 200 mg / kg, p.o.) of Rehmanniae radix aquosa were slightly decreased.
3. The serum triglyceride levels of streptozotocin-induced hyperglycemic rats were significantly decreased by the administrations of the water fractions(100mg / kg, 200mg / kg, p.o.) and the methanol fractions(100mg / kg, 200mg / kg, p.o.) of Relumanniae Radices.
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